Yes. While this applies to most applications, it’s not consistent between games. Ubisoft games, for instance, are notorious for their menu systems failing notice a system-set button reversal. In those cases I can set the R-button for primary fire / select and the L-button for secondary (Hacker-vision in Watch Dogs 2, for instance, since I aim / use iron-sights with Numpad-5) but any in-game menus still require an unreversible left-click, which I have to either deal with or work around.
Yes. While this applies to most applications, it’s not consistent between games. Ubisoft games, for instance, are notorious for their menu systems failing notice a system-set button reversal. In those cases I can set the R-button for primary fire / select and the L-button for secondary (Hacker-vision in Watch Dogs 2, for instance, since I aim / use iron-sights with Numpad-5) but any in-game menus still require an unreversible left-click, which I have to either deal with or work around.