![[Paper] Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake - 2021 [Junk]](https://hackertalks.com/pictrs/image/8f965b98-56ed-41e7-a961-b2efaeccbe7b.jpeg){kind=link}
The carbohydrate–insulin model of obesity posits that high-carbohydrate diets lead to excess insulin secretion, thereby promoting fat accumulation and increasing energy intake. Thus, low-carbohydrate diets are predicted to reduce ad libitum energy intake as compared to low-fat, high-carbohydrate diets. To test this hypothesis, 20 adults aged 29.9 ± 1.4 (mean ± s.e.m.) years with body mass index of 27.8 ± 1.3 kg m−2 were admitted as inpatients to the National Institutes of Health Clinical Center and randomized to consume ad libitum either a minimally processed, plant-based, low-fat diet (10.3% fat, 75.2% carbohydrate) with high glycemic load (85 g 1,000 kcal−1) or a minimally processed, animal-based, ketogenic, low-carbohydrate diet (75.8% fat, 10.0% carbohydrate) with low glycemic load (6 g 1,000 kcal−1) for 2 weeks followed immediately by the alternate diet for 2 weeks. One participant withdrew due to hypoglycemia during the low-carbohydrate diet. The primary outcomes compared mean daily ad libitum energy intake between each 2-week diet period as well as between the final week of each diet. We found that the low-fat diet led to 689 ± 73 kcal d−1 less energy intake than the low-carbohydrate diet over 2 weeks (P < 0.0001) and 544 ± 68 kcal d−1 less over the final week (P < 0.0001). Therefore, the predictions of the carbohydrate–insulin model were inconsistent with our observations. This study was registered on ClinicalTrials.gov as NCT03878108.
Paywall - https://doi.org/10.1038/s41591-020-01209-1
Full paper is on the pirate academic sites.
my (barely educated) guess is the fiber in the LFPB diet is what causes participants’ energy intake to be lower
This study doesn’t cover it! both diets were mostly plant based, the paper title is a political device. The animal base low carb diet had tons of fiber and plants. If you look at the actual data of the paper, ad libitum energy is HIGHER on the high carb diet.
Just for fun, from the supplementary material, here is a real photo of the ANIMAL BASED snacks supplied to the low carb group - this is what the ad libitum is talking about, they could eat as many snacks as they wanted.
Ah yes that famous animal the peanut
Sure as hell looks like plants to me…
did they mangle the data analysis that badly? it looks like there was a pretty clear difference in energy intake between the two diets unless I’m reading the charts wrong
the use of “animal/plant” based in the text does come off as odd and vaguely political. though so vague I can’t tell if the authors are pro- or anti- animal-based foods
Hall is very deep in the pro-plant camp.
They didn’t mangle the data-analysis, they did gymnastics to prove their thesis - hence the need for other researchers to do a re-analysis of their own data but separating out the groups by diet order.
But even if restrict yourself to Halls paper, even with a higher energy intake on low carb, people lost more fat mass - That does not contradict the carbohydrate insulin model. The fact they are saying this isn’t CIM is by implicitly assuming CICO drives fat mass is pre-supposing their conclusion in the analysis, which their own graphs contradict!
I sure as hell wouldn’t use any study with a 14 day duration to inform my understanding of weight loss dieting lol