Viral snares/traps? Semi-permeable membrane + RNA; the virus gets in and binds to the RNA inside, then the viral package is “spent” on fake RNA that can’t replicate. The MVP shell could keep regular cellular machinery away from the trap RNA. There are thousands of these vaults within the cell, as to create a bunch of “pits” that a virus could fall into, thus effectively slowing viral spread, even a little?
vault protein somehow helps epithelial cells internalize P. aeruginosa, which in turn speeds the clearance of an infection. Compared to normal mice, for example, MVP-less mice were 3 times as likely to die when their lungs were infected with the bacterium
This was mentioned as a hypothesis that was determined to be fruitless. Was this ever explored further? Different viruses, organ systems, etc.? Since it’s in a lot of different organisms, maybe some common virus that affects many different species is affected by this.
My wild speculation:
Viral snares/traps? Semi-permeable membrane + RNA; the virus gets in and binds to the RNA inside, then the viral package is “spent” on fake RNA that can’t replicate. The MVP shell could keep regular cellular machinery away from the trap RNA. There are thousands of these vaults within the cell, as to create a bunch of “pits” that a virus could fall into, thus effectively slowing viral spread, even a little?
edit: from a link in the article:
This was mentioned as a hypothesis that was determined to be fruitless. Was this ever explored further? Different viruses, organ systems, etc.? Since it’s in a lot of different organisms, maybe some common virus that affects many different species is affected by this.
This is very interesting.